| Date | Location | Result | |
| Nov 19, 2005 | Chapel Hill | North Carolina 24, Duke 21 | Box score |
| Nov 03, 2005 | Clemson, SC | Clemson 49, Duke 20 | Box score |
| Oct 29, 2005 | Durham, N.C. | Wake Forest 44, Duke 6 | Box score |
| Oct 22, 2005 | Durham, N.C. | Florida State 55, Duke 24 | Box score |
| Oct 15, 2005 | Durham, N.C. | Georgia Tech 35, Duke 10 | Box score |
| Oct 08, 2005 | Miami, Fla. | Miami 52, Duke 7 | Box score |
| Oct 01, 2005 | Durham, N.C. | Navy 28, Duke 21 | Box score |
| Sep 24, 2005 | Charlottesville, Va. | Virginia 38, Duke 7 | Box score |
| Sep 17, 2005 | Durham, N.C. | Duke 40, VMI 14 | Box score |
| Sep 10, 2005 | Durham, N.C. | Virginia Tech 45, Duke 0 | Box score |
| Sep 03, 2005 | Greenville, N.C. | East Carolina 24, Duke 21 | Box score |