| Date | Location | Result | |
| Nov 27, 2010 | Durham, N.C. | North Carolina 24, Duke 19 | Box score |
| Nov 20, 2010 | Atlanta, Ga. | Georgia Tech 30, Duke 20 | Box score |
| Nov 13, 2010 | Durham, N.C. | Boston College 21, Duke 16 | Box score |
| Nov. 6, 2010 | Durham, N.C. | Duke 55, Virginia 48 | Box score |
| Oct 30, 2010 | Annapolis, Md. | Duke 34, Navy 31 | Box score |
| Oct 23, 2010 | Blacksburg, Va. | Virginia Tech 44, Duke 7 | Box score |
| Oct 16, 2010 | Durham, N.C. | Miami 28, Duke 13 | Box score |
| Oct 02, 2010 | College Park, Md. | Maryland 21, Duke 16 | Box score |
| Sep 25, 2010 | Durham, N.C. | Army 35, Duke 21 | Box score |
| Sep 18, 2010 | Durham, N.C. | Alabama 62, Duke 13 | Box score |
| Sep 11, 2010 | Winston-Salem, N.C. | Wake Forest 54, Duke 48 | Box score |
| Sep 04, 2010 | Durham, N.C. | Duke 41, Elon 27 | Box score |